Goserelin + Flutamide + RT

Indication

Hormonal and radiation therapy for localized cancer

• Goserelin (Zoladex) 3.6 mg sc q4w 2 months before radiotherapy and then during radiotherapy
• Flutamide (Eulexin) 250 mg po tid 2 months before radiotherapy and then during radiotherapy
• Radiotherapy 70 Gy

References

Pilepich, MV et al. Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate. Int J Radiat Oncol Biol Phys 2001; 50:1243